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There are several matches for 'Aldo/keto reductase'.
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23681 matches
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organism
protein
1)
Mus musculus
Akr1c20 -
Aldo
-
keto
reductase
family 1, member C20.
[a.k.a. UPI0000028789, ENSMUSP00000079232, 116852]
2)
Homo sapiens
AKR1C2 -
Aldo
-
keto
reductase
family 1 member C2; Works in concert with the 5-alpha/5-beta-steroid
reductases
to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5- beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha- androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
[a.k.a. P52895, ENSP00000397161, uc057rik.1]
3)
Homo sapiens
AKR1D1 -
Aldo
-
keto
reductase
family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one). Belongs to the aldo/keto
reductase
family.
[a.k.a. ENST00000470851, UPI00017A769E, AKR1D1-204]
4)
Homo sapiens
AKR1B1 -
Aldo
-
keto
reductase
family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...]
[a.k.a. 1T41, 2INE, ENST00000465351]
5)
Homo sapiens
AKR1B10 -
Aldo
-
keto
reductase
family 1 member B10; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans- retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4- hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no
reductase
activity towards glucose.
[a.k.a. R-HSA-388396, HSI, R-HSA-196854]
6)
Homo sapiens
AKR1A1 -
Aldo
-
keto
reductase
family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions [...]
[a.k.a. HPA019649, ENSG00000117448, ENST00000434299.5]
7)
Homo sapiens
AKR1C4 -
Aldo
-
keto
reductase
family 1 member C4; Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan- 3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha- hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route; Belongs to the aldo/keto
reductase
family.
[a.k.a. R-HSA-388396, R-HSA-196854, hsa:1109]
8)
Homo sapiens
AKR1C3 -
Aldo
-
keto
reductase
family 1 member C3; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone; Belongs to the aldo/keto
reductase
family.
[a.k.a. R-HSA-388396, ENST00000602997, R-HSA-196854]
9)
Homo sapiens
AKR1C1 -
Aldo
-
keto
reductase
family 1 member C1; Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation; Belongs to the aldo/keto
reductase
family.
[a.k.a. P52896, R-HSA-388396, ENST00000477661]
10)
Homo sapiens
AKR1B15 -
Aldo
-
keto
reductase
family 1 member B15; [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta- hydroxysteroid dehydrogenase activity) as well as 3-
keto
-acyl-CoAs. Displays strong enzymatic activity toward all-trans- retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism.
[a.k.a. CCDS47715, NP_001074007.2, ENST00000423958]
11)
Homo sapiens
AKR1C8P -
Aldo
-
keto
reductase
family 1 member C8, pseudogene.
[a.k.a. ENST00000584929, ENSP00000462351, ENSP00000463059]
12)
Mus musculus
Akr1b10 -
Aldo
-
keto
reductase
family 1, member B10 (aldose
reductase
).
[a.k.a. MGI:1915111, NP_765986.3, ENSMUST00000144072.1]
13)
Mus musculus
Akr1c18 -
Aldo
-
keto
reductase
family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP); Belongs to the aldo/keto
reductase
family.
[a.k.a. mmu:105349, Akr1c18-201, NP_598827.1]
14)
Mus musculus
Akr1c21 -
Aldo
-
keto
reductase
family 1 member C21; NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3- alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17- ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of
keto
groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3- ketosteroids yields only 3-alpha-hydroxysteroids. Belongs to the aldo/keto
reductase
family.
[a.k.a. DD3, UPI000B3D7C8D, ENSMUSG00000021207]
15)
Mus musculus
Akr1b7 -
Aldo
-
keto
reductase
family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins. May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity); Belongs to the aldo/keto
reductase
family.
[a.k.a. NP_033861.2, MVDP, 1.1.1.21]
16)
Mus musculus
Akr1c12 -
Aldo
-
keto
reductase
family 1, member C12.
[a.k.a. 622402, AF177041, Aldo-keto reductase family 1, member C12]
17)
Mus musculus
Akr1c13 -
Aldo
-
keto
reductase
family 1 member C13; Catalyzes the dehydrogenation of 17-beta-hydroxysteroids. May also exhibit significant activity with a variety of cyclic and alicyclic alcohols. Uses both NAD and NADP, but the activity is much greater with NAD than with NADP (By similarity).
[a.k.a. Aldo-keto reductase family 1, member C13, CCDS26220.1, Akr1c13-203]
18)
Mus musculus
Akr1a1 -
Aldo
-
keto
reductase
family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone. Functions as a detoxifiying enzyme b [...]
[a.k.a. Q9CT53, NP_067448.1, AK164461]
19)
Mus musculus
Akr1d1 -
Aldo
-
keto
reductase
family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto
reductase
family.
[a.k.a. Akr1d1-201, XM_017321478, XP_017176967.1]
20)
Mus musculus
Akr1cl -
Aldo
-
keto
reductase
family 1, member C-like.
[a.k.a. ENSMUSG00000025955, ENSMUST00000159896.1, NP_081858.2]
23681 matches
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